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  • Pulsatilla vulgaris Mill. Ranunculaceae. Pasque flower. Distribution: Europe. Lindley (1838) and Woodville (1790) knew this as Anemone pulsatilla, the common name being Pasque (Easter) Flower. At the end of the 18th century it was recommended for blindness, cataracts, syphilis, strokes and much more, treatments which, as was clear to physicians at the time, were valueless. Gerard (1633) writes: ‘They serve only for the adorning of gardens and garlands, being floures of great beauty’. It is in the buttercup family, Ranunculaceae, all members of which are poisonous. It was recommended, by mouth, for ‘obstinate case of taenia’ (tapeworms). One hopes it was more toxic to the worm than the patient. Flowers with a central disc and radiating florets were regarded as being good for eye complaints under the Doctrine of Signatures. Porta (1588) writes (translated): ‘Argemone [Papaver argemone], and anemone, have flowers of this shape, from this they cure ulcers and cloudiness of the cornea’. There were occupational diseases even before there were words like pneumoconiosis, and Lindley writes that ‘the powder of the root causes itching of the eyes, colic and vomiting, if in pulverising it the operator do not avoid the fine dust which is driven up.’ Photographed in the Medicinal Garden of the Royal College of Physicians, London.
  • Pulsatilla vulgaris Mill. Ranunculaceae Pasque flower. Distribution: Europe. Lindley (1838) and Woodville (1790) knew this as Anemone pulsatilla, the common name being Pasque (Easter) Flower. At the end of the 18th century it was recommended for blindness, cataracts, syphilis, strokes and much more, treatments which, as was clear to physicians at the time, were valueless. Gerard (1633) writes: ‘They serve only for the adorning of gardens and garlands, being floures of great beauty’. It is in the buttercup family, Ranunculaceae, all members of which are poisonous. It was recommended, by mouth, for ‘obstinate case of taenia’ (tapeworms). One hopes it was more toxic to the worm than the patient. Flowers with a central disc and radiating florets were regarded as being good for eye complaints under the Doctrine of Signatures. Porta (1588) writes (translated): ‘Argemone [Papaver argemone], and anemone, have flowers of this shape, from this they cure ulcers and cloudiness of the cornea’. There were occupational diseases even before there were words like pneumoconiosis, and Lindley writes that ‘the powder of the root causes itching of the eyes, colic and vomiting, if in pulverising it the operator do not avoid the fine dust which is driven up.’ Photographed in the Medicinal Garden of the Royal College of Physicians, London.
  • Capsicum annuum 'Masquerade' Distribution: Central and South America. This ‘domesticated species’ originated from Mexico (although the centre of Capsicum evolution was much earlier and from Bolivia) and includes the bland salad peppers and the hot chilli peppers, of which capsaicin (sometimes called capsicain), from the lining of the inside of the chilli, is the main active ingredient. Chilli comes from the Aztec language of the Nahuatl people. It was reputedly introduced to Europe by Columbus in the mid-15th century, but was cultivated in Mexico since 4,000 BCE and used in cooking since 7,200 BCE. After its introduction to Europe, its cultivation very rapidly became world-wide. It appears first as a description (Bock, 1539) with the name teutschem Pfeffer. The first illustration, as Siliquastrum, appears in Historia Stirpes commentarii insignis (Fuchs, 1542). Fuchs did not realise it came from the Americas, as he identified it as a plant described by Pliny, Dioscorides and Avicenna and gave their uses of it. It appear in Dodoen's Cruydeboeck (1551) and Lyte's translation (1557) with the note that it is 'hot and drie in the third degree.' He recommended it for dressing meat, and noted that it 'warmeth the stomach' and was good for a sore throat, scrofula, and topically got rid of spots. Fuch's had reported these properties as being described by Avicenna, but what that plant was is unknown. Lindley (1838) wrote: 'It is employed in medicine, in combination with Cinchona in intermittent and lethargic affections, and also in atonic gout, dyspepsia accompanied by flatulence, tympanitis, paralysis etc. Its most valuable application appears however to be in cynanche maligna [=severe sore throat, with impending suffocation] and scarlatina maligna [=severe scarlet fever], used either as a gargle or administered internally.' However, its principal use medically has been in pain relief, applied locally for pain from muscle injury to post herpetic neuralgia. Capsaicin acts on the pain and heat sensing neurones to make them trigger the sensation of pain at body temperature. Repeated exposure to capsaicin depletes the neurotransmitter substance P that is used to perceive pain, so the relevant nerves no longer transmit the sensation of pain/heat from any cause. It is a banned substance in the equestrian events at the Olympics because of its ability to stop perception of pain. Capsaicin has been shown, experimentally, to kill cancer cells by attacking their mitochondria. Particular interest has concentrated on its ability to reduce the size of tumours of the pancreas and prostate. Various cultivars are used in cooking, and the strength (i.e. how hot they are) is measured in Scoville units. A standard chilli pepper used in England would be around 5,000 Scovilles, the hottest peppers are rated over one million Scoville units. Photographed in the Medicinal Garden of the Royal College of Physicians, London.
  • Atropa belladonna L. Solanaceae. Deadly nightshade. Dwale. Morella, Solatrum, Hound's berries, Uva lupina, Cucubalus, Solanum lethale. Atropa derives from Atropos the oldest of the three Fates of Greek mythology who cut the thread of Life (her sisters Clotho and Lachesis spun and measured the thread, respectively). belladonna, literally, means 'beautiful lady' and was the Italian name for it. Folklore has it that Italian ladies put drops from the plant or the fruits in their eyes to make themselves doe-eyed, myopic and beautiful. However, this is not supported by the 16th and 17th century literature, where no mention is ever made of dilated pupils (or any of the effects of parasympathetic blockade). Tournefort (1719) says 'The Italians named this plant Belladonna, which in their language signifies a beautiful woman, because the ladies use it much in the composition of their Fucus [rouge or deceit or cosmetic] or face paint.' Parkinson says that the Italian ladies use the distilled juice as a fucus '... peradventure [perhaps] to take away their high colour and make them looke paler.' I think it more likely that they absorbed atropine through their skin and were slightly 'stoned' and disinhibited, which made them beautiful ladies in the eyes of Italian males. Distribution: Europe, North Africa, western Asia. Culpeper (1650) writes: 'Solanum. Nightshade: very cold and dry, binding … dangerous given inwardly … outwardly it helps the shingles, St Antonie's Fire [erysipelas] and other hot inflammation.' Most of the 16th, 17th and 18th century herbals recommend it topically for breast cancers. Poisonous plants were regarded as 'cold' plants as an excess of them caused death and the body became cold. They were regarded as opposing the hot humour which kept us warm and alive. Poultices of Belladonna leaves are still recommended for muscle strain in cyclists, by herbalists. Gerard (1633) writes that it: 'causeth sleep, troubleth the mind, bringeth madnesse if a few of the berries be inwardly taken, but if more be taken they also kill...'. He was also aware that the alkaloids could be absorbed through the skin for he notes that a poultice of the leaves applied to the forehead, induces sleep, and relieves headache. The whole plant contains the anticholinergic alkaloid atropine, which blocks the peripheral actions of acetylcholine in the parasympathetic nervous system. Atropine is a racemic mixture of d- and l- hyoscyamine. Atropine, dropped into the eyes, blocks the acetylcholine receptors of the pupil so it no longer constricts on exposure to bright light - so enabling an ophthalmologist to examine the retina with an ophthalmoscope. Atropine speeds up the heart rate, reduces salivation and sweating, reduces gut motility, inhibits the vertigo of sea sickness, and is used to block the acetylcholine receptors to prevent the effects of organophosphorous and other nerve gas poisons. It is still has important uses in medicine. Atropine poisoning takes three or for days to wear off, and the hallucinations experienced by its use are described as unpleasant. We have to be content with 'madness', 'frenzie' and 'idle and vain imaginations' in the early herbals to describe the hallucinations of atropine and related alkaloids as the word 'hallucination' in the sense of a perception for which there is no external stimulus, was not used in English until 1646 (Sir T. Browne, 1646). It is a restricted herbal medicine which can only be sold in premises which are registered pharmacies and by or under the supervision of a pharmacist (UK Medicines and Healthcare Products Regulatory Agency (MHRA)). Photographed in the Medicinal Garden of the Royal College of Physicians, London.
  • Paris quadrifolia L. Trilliaceae Herb Paris Distribution: Europe and temperate Asia. This dramatic plant was known as Herb Paris or one-berry. Because of the shape of the four leaves, resembling a Burgundian cross or a true love-knot, it was also known as Herb True Love. Prosaically, the name ‘Paris’ stems from the Latin ‘pars’ meaning ‘parts’ referring to the four equal leaves, and not to the French capital or the lover of Helen of Troy. Sixteenth century herbalists such as Fuchs, who calls it Aconitum pardalianches which means leopard’s bane, and Lobel who calls it Solanum tetraphyllum, attributed the poisonous properties of Aconitum to it. The latter, called monkshood and wolfsbane, are well known as poisonous garden plants. Gerard (1633), however, reports that Lobel fed it to animals and it did them no harm, and caused the recovery of a dog poisoned deliberately with arsenic and mercury, while another dog, which did not receive Herb Paris, died. It was recommended thereafter as an antidote to poisons. Coles (1657) wrote 'Herb Paris is exceedingly cold, wherupon it is proved to represse the rage and force of any Poyson, Humour , or Inflammation.' Because of its 'cold' property it was good for swellings of 'the Privy parts' (where presumably hot passions were thought to lie), to heal ulcers, cure poisoning, plague, procure sleep (the berries) and cure colic. Through the concept of the Doctrine of Signatures, the black berry represented an eye, so oil distilled from it was known as Anima oculorum, the soul of the eye, and 'effectual for all the disease of the eye'. Linnaeus (1782) listed it as treating 'Convulsions, Mania, Bubones, Pleurisy, Opththalmia', but modern authors report the berry to be toxic. That one poison acted as an antidote to another was a common, if incorrect, belief in the days of herbal medicine. Photographed in the Medicinal Garden of the Royal College of Physicians, London.
  • Annals of the Royal Society Club : the record of a London dining-club in the eighteenth & nineteenth centuries, by Sir Archibald Geikie ... / [Sir Archibald Geikie].
  • Smithfield Market.
  • Milk Fair in St. James's Park.
  • Northumberland House.
  • Lansdowne House.
  • Opium den, East end
  • Dickens :" Drinking Party at Bob Sawyers "
  • Dickens :" Bob Sawyer on the roof of chaise "
  • London slums
  • A cowshed in Drury lane about 1850. About eight cows were kept in these premises in order to supply families in the nieghbourhood with milk. They were kept in almost complete darkness and so close together that they were almost touching. Some were even kept in the cellar.
  • Harrow alley, Houndsditch
  • Wentworth st, Whitechapel
  • Peabody Square, Westminter. Dwellings for the poor.
  • A blind man walks in Covent Garden, begging for money with hat and placard, stops at two ladies, one who gives him money, meanwhile a young fop helps a lady from a carriage. Coloured etching by T. Rowlandson, c. 1802.
  • Royal College of Physicians, Warwick Lane, London, with a public house shown on the corner. Engraving after T. H. Shepherd.
  • Head of a man expressing acute pain. Pencil drawing after Charles Le Brun.
  • Royal College of Physicians, Warwick Lane, London, in 1841. Wood engraving.
  • The London Institution: the interior of the library. Engraving by J. Carter after H. Ansted, 1824.
  • Fishmongers' Hall, Thames Street, London: the entrance to the hall, with elaborate allegorical carving above the doors, two fashionable ladies, a scholar and a coal-heaver in the street. Engraving by J. Greig after T. H. Shepherd, 1830.
  • Russell Institution, Great Coram Street, London: the facade, above, floor plan, below, with a scale of feet. Engraving by J. Le Keux after G. Cattermole, 1824.
  • Bagnigge Wells: the gardens, with people taking tea, playing bowls, etc. Coloured process print after a drawing made in 1830.
  • Russell Institution, Great Coram Street, London: the facade, with passers-by. Engraving by J. Carter after T. H. Shepherd 1828.
  • A doctor in a strange hat. Watercolour, 1815.
  • A species of orchid: flowering plant with traces of surrounding vegetation. Chromolithograph by E.Vouga, c.1883, after herself.
  • The London Institution: the interior of the library. Drawing by H. Ansted, 1824.