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  • Aconitum carmichaelii Debeaux. Ranunculaceae. Chinese aconite, Chinese wolfsbane, Carmichael's monkshood. Herbaceous perennial. Distribution C. to W. China to N. America. Named for Dr J.R. Carmichael (d. 1877), English physician, plant collector and Protestant missionary from 1862-1877 in Guangdong and Shandong, China initially in Canton. He aided Francis Forbes to collect plants for Kew. Aconitum plants are so poisonous that Theophrastus states that death was the punishment for possessing them. Aconitine is the poison and was used - from Aconitum ferox - in the 'curry murder' in London in 2009. It causes respiratory paralysis, bradycardia (slowing of the pulse), cardiac arrhythmias, tingling, sweating, gastric cramps, diarrhoea and death, both by ingestion and by absorption through the mucous membranes and the skin. Despite this it is widely used in Chinese herbal medicine. It is a restricted herbal medicine which can only be dispensed by a herbal practitioner for external use following a one-to-one consultation, or by prescription from a registered doctor or dentist (UK Medicines and Healthcare Products Regulatory Agency (MHRA)). Photographed in the Medicinal Garden of the Royal College of Physicians, London.
  • Veratrum nigrum L. Melanthiaceae Distribution: Europe. Cows do not eat Veratrum species in the meadows, and human poisoning with it caused vomiting and fainting. In the 1850s it was found to reduce the heart's action and slow the pulse (Bentley, 1861, called it an 'arterial sedative'), and in 1859 it was used orally in a woman who was having convulsions due to eclampsia. Dr Paul DeLacy Baker in Alabama treated her with drops of a tincture of V. viride. She recovered. It was used thereafter, as the first choice of treatment, and, when blood pressure monitoring became possible, it was discovered that it worked by reducing the high blood pressure that occurs in eclampsia. By 1947 death rates were reduced from 30% to 5% by its use at the Boston Lying-in Hospital. It works by dilating the arteries in muscles and in the gastrointestinal circulation. A further use of Veratrum species came to light when it was noted that V. californicum - and other species - if eaten by sheep resulted in foetal malformations, in particular only having one eye. The chemical in the plant that was responsible, cyclopamine, was found to act on certain genetic pathways responsible for stem cell division in the regulation of the development of bilateral symmetry in the embryo/foetus. Synthetic analogues have been developed which act on what have come to be called the 'hedgehog signalling pathways' in stem cell division, and these 'Hedgehog inhibitors' are being introduced into medicine for the treatment of various cancers like chondrosarcoma, myelofibrosis, and advanced basal cell carcinoma. The drugs are saridegib, erismodegib and vismodegib. All the early herbals report on its ability to cause vomiting. As a herbal medicine it is Prescription Only, via a registered dentist or physician (UK Medicines and Healthcare Products Regulatory Agency (MHRA)). Photographed in the Medicinal Garden of the Royal College of Physicians, London.
  • Veratrum album L. Melanthiaceae Distribution: Europe. Cows do not eat Veratrum species in the meadows, and human poisoning with it caused vomiting and fainting. In the 1850s it was found to reduce the heart's action and slow the pulse (Bentley, 1861, called it an 'arterial sedative'), and in 1859 it was used orally in a woman who was having convulsions due to eclampsia. Dr Paul DeLacy Baker in Alabama treated her with drops of a tincture of V. viride. She recovered. It was used thereafter, as the first choice of treatment, and when blood pressure monitoring became possible, it was discovered that it worked by reducing the high blood pressure that occurs in eclampsia. By 1947 death rates were reduced from 30% to 5% by its use at the Boston Lying in Hospital. It works by dilating the arteries in muscles and in the gastrointestinal circulation. A further use of Veratrum species came to light when it was noted that V. californicum -and other species - if eaten by sheep resulted in foetal malformations, in particular only having one eye. The chemical in the plant that was responsible, cyclopamine, was found to act on certain genetic pathways responsible for stem cell division in the regulation of the development of bilateral symmetry in the embryo/foetus. Synthetic analogues have been developed which act on what have come to be called the 'hedgehog signalling pathways' in stem cell division, and these 'Hedgehog inhibitors' are being introduced into medicine for the treatment of various cancers like chondrosarcoma, myelofibrosis, and advanced basal cell carcinoma. The drugs are saridegib, erismodegib and vismodegib. All the early herbals report on its ability to cause vomiting. As a herbal medicine it is Prescription Only, via a registered dentist or physician (UK Medicines and Healthcare Products Regulatory Agency (MHRA)). Photographed in the Medicinal Garden of the Royal College of Physicians, London.
  • Diagnostic test for Fragile X, using presence (normal) or absence (Fragile X syndrome) of FMR-1 protein. FMR-1 protein expression in blood cells has been made visible with antibodies against the FMR-1 protein. The presence of FMR-1 protein is made visible as red staining. a: red staining in cells of normal individual. b/c: absence of staining in male patient. d: female patient; one cell is showing staining and in the other cell there is an absence of staining - this individual is a carrier.
  • C15 Chinese medical primer: Correlations of the pulses
  • Ming Chinese wheel diagram of the channels
  • Theory of diseases treated with Minor Bupleurum decoction