Prostate cancer cell

Prostate cancer cells

Prostate cancer cell, SEM

Prostate cancer cell spheroid, LM

Prostate cancer cell spheroid, SEM

Prostate cancer cells treated with curcumin, LM

Prostate cancer cells treated with nano sized drug carriers

Castration resistant prostate cancer, human tissue

Capsicum annuum 'Masquerade' Distribution: Central and South America. This ‘domesticated species’ originated from Mexico (although the centre of Capsicum evolution was much earlier and from Bolivia) and includes the bland salad peppers and the hot chilli peppers, of which capsaicin (sometimes called capsicain), from the lining of the inside of the chilli, is the main active ingredient. Chilli comes from the Aztec language of the Nahuatl people. It was reputedly introduced to Europe by Columbus in the mid-15th century, but was cultivated in Mexico since 4,000 BCE and used in cooking since 7,200 BCE. After its introduction to Europe, its cultivation very rapidly became world-wide. It appears first as a description (Bock, 1539) with the name teutschem Pfeffer. The first illustration, as Siliquastrum, appears in Historia Stirpes commentarii insignis (Fuchs, 1542). Fuchs did not realise it came from the Americas, as he identified it as a plant described by Pliny, Dioscorides and Avicenna and gave their uses of it. It appear in Dodoen's Cruydeboeck (1551) and Lyte's translation (1557) with the note that it is 'hot and drie in the third degree.' He recommended it for dressing meat, and noted that it 'warmeth the stomach' and was good for a sore throat, scrofula, and topically got rid of spots. Fuch's had reported these properties as being described by Avicenna, but what that plant was is unknown. Lindley (1838) wrote: 'It is employed in medicine, in combination with Cinchona in intermittent and lethargic affections, and also in atonic gout, dyspepsia accompanied by flatulence, tympanitis, paralysis etc. Its most valuable application appears however to be in cynanche maligna [=severe sore throat, with impending suffocation] and scarlatina maligna [=severe scarlet fever], used either as a gargle or administered internally.' However, its principal use medically has been in pain relief, applied locally for pain from muscle injury to post herpetic neuralgia. Capsaicin acts on the pain and heat sensing neurones to make them trigger the sensation of pain at body temperature. Repeated exposure to capsaicin depletes the neurotransmitter substance P that is used to perceive pain, so the relevant nerves no longer transmit the sensation of pain/heat from any cause. It is a banned substance in the equestrian events at the Olympics because of its ability to stop perception of pain. Capsaicin has been shown, experimentally, to kill cancer cells by attacking their mitochondria. Particular interest has concentrated on its ability to reduce the size of tumours of the pancreas and prostate. Various cultivars are used in cooking, and the strength (i.e. how hot they are) is measured in Scoville units. A standard chilli pepper used in England would be around 5,000 Scovilles, the hottest peppers are rated over one million Scoville units. Photographed in the Medicinal Garden of the Royal College of Physicians, London.

Helianthus annuus Greene Asteraceae. Sunflower, Marigold of Peru, Floure of the Sun. Distribution: Peru and Mexico. It was much recommended by Gerard (1633) who advises that the buds, covered in flour, boiled, and eaten with 'butter, vinegar and pepper, far surpass artichokes in procuring bodily lust’. Sadly, today only the seeds of sunflower are consumed, as the source of sunflower seed oil used in cooking. It contains mono and polyunsaturated fats, linoleic acid and oleic acid, and is low in saturated fats. As such it was thought to lower cholesterol and so the risk of heart disease, but it may increase the risk of breast and prostatic cancer. However a recent report BMJ2013

Detecting cancer in human tissues, LM

Taxus baccata L. Taxaceae European Yew. Trees are feminine in Latin, so while Taxus has a masculine ending (-us), its specific name, baccata (meaning 'having fleshy berries' (Stearn, 1994)), agrees with it in gender by having a female ending ( -a). Distribution: Europe. Although regarded as poisonous since Theophrastus, Gerard and his school friends used to eat the red berries (they are technically called 'arils') without harm. Johnson clearly ate the fleshy arils and spat out the seed, which is as poisonous as the leaves. It is a source of taxol, an important chemotherapeutic agent for breast and other cancers. It was first extracted from the bark of T. brevifolia, the Pacific yew tree, in 1966. About 1,100 kg of bark produces 10 g of taxol, and 360,000 trees a year would have been required for the needs of the USA – an unsustainable amount. In 1990 a precursor of taxol was extracted from the needles of the European yew so saving the Pacific trees. It is now produced in fermentation tanks from cell cultures of Taxus. Curiously, there is a fungus, Nodulisporium sylviforme, which lives on the yew tree, that also produces taxol. Because taxol stops cell division, it is also used in the stents that are inserted to keep coronary arteries open. Here it inhibits – in a different way, but like anti-fouling paint on the bottom of ships – the overgrowth of endothelial cells that would otherwise eventually block the tube. The economic costs of anticancer drugs are significant. Paclitaxel ‘Taxol’ for breast cancer costs (2012) £246 every 3 weeks

BRCA1 during meiosis

Meiosis

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