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  • C14 Chinese medication chart: Convulsions etc.
  • Paediatric acu-moxa: infantile convulsions, Chinese woodcut
  • Qing Chinese paediatric diagnosis chart for convulsions
  • Acu-moxa chart: Infantile convulsions, Chinese MS, c. 1911
  • A naked woman sitting in a chair having convulsions. Collotype after Eadweard Muybridge, 1887.
  • A woman on the ground with artificially induced convulsions. Collotype after Eadweard Muybridge, 1887.
  • A woman on the ground with artificially induced convulsions. Collotype after Eadweard Muybridge, 1887.
  • A woman on the ground with artificially induced convulsions. Collotype after Eadweard Muybridge, 1887.
  • A mesmerist using animal magnetism on a woman who responds with convulsions. Wood engraving, 1845.
  • A mesmerist using animal magnetism on a woman who responds with convulsions. Wood engraving, 1845.
  • Members of the Jansenist sect having convulsions and spasms as a result of religious fanaticism. Engraving by B. Picart.
  • Members of the Jansenist sect having convulsions and spasms as a result of religious fanaticism. Engraving by B. Picart.
  • The Infant's Preservative : for complaints in the bowels of infants, as wind, gripes, convulsions, &c. for preventing the tooth fever, and rendering the operation of dentition easy and free from danger, for preventing the rickets, and for laying the foundation of a good constitution / prepared by John Atkinson.
  • Medicina gerocomica: or, the Galenic art of preserving old men's healths. Explained in twenty chapters. To which is added an appendix, concerning the use of oyls and unction, in the prevention and cure of some diseases. As also a method ... of curing convulsions and epilepsies, by external operation / By Sir John Floyer.
  • Acanthus spinosus L. Acanthaceae. Bears breeches. Distribution: Southern Europe to Western Turkey. Herbaceous perennial flowering plant. Named for spiny leaves. Dioscorides recommended the roots applied for inflammation and spasms, and -when drunk- to promote urine, check diarrhoea, and for phthysis, ruptures and convulsions. The leaves are the model for those at the top of Corinthian columns. Tetraglycosides isolated from the plant show cytotoxicity in sea urchin eggs and crown gall tumour on potato disks. Photographed in the Medicinal Garden of the Royal College of Physicians, London.
  • Mrs John Webb, being nursed when sick in bed with "a dead palsey, and ... convulsion in the nerves", before being cured by Sir William Read. Engraving by M. Burghers, ca. 1700.
  • Paris quadrifolia L. Trilliaceae Herb Paris Distribution: Europe and temperate Asia. This dramatic plant was known as Herb Paris or one-berry. Because of the shape of the four leaves, resembling a Burgundian cross or a true love-knot, it was also known as Herb True Love. Prosaically, the name ‘Paris’ stems from the Latin ‘pars’ meaning ‘parts’ referring to the four equal leaves, and not to the French capital or the lover of Helen of Troy. Sixteenth century herbalists such as Fuchs, who calls it Aconitum pardalianches which means leopard’s bane, and Lobel who calls it Solanum tetraphyllum, attributed the poisonous properties of Aconitum to it. The latter, called monkshood and wolfsbane, are well known as poisonous garden plants. Gerard (1633), however, reports that Lobel fed it to animals and it did them no harm, and caused the recovery of a dog poisoned deliberately with arsenic and mercury, while another dog, which did not receive Herb Paris, died. It was recommended thereafter as an antidote to poisons. Coles (1657) wrote 'Herb Paris is exceedingly cold, wherupon it is proved to represse the rage and force of any Poyson, Humour , or Inflammation.' Because of its 'cold' property it was good for swellings of 'the Privy parts' (where presumably hot passions were thought to lie), to heal ulcers, cure poisoning, plague, procure sleep (the berries) and cure colic. Through the concept of the Doctrine of Signatures, the black berry represented an eye, so oil distilled from it was known as Anima oculorum, the soul of the eye, and 'effectual for all the disease of the eye'. Linnaeus (1782) listed it as treating 'Convulsions, Mania, Bubones, Pleurisy, Opththalmia', but modern authors report the berry to be toxic. That one poison acted as an antidote to another was a common, if incorrect, belief in the days of herbal medicine. Photographed in the Medicinal Garden of the Royal College of Physicians, London.
  • Scutellaria baicalensis Georgi Lamiaceae. Baikal skullcap. Distribution: China. There are several hundred species of Scutellaria, also known as skull caps, so correct identification is important - in particular from Scutellaria lateriflora an American species known as Blue skullcap. The latter is used as an abortifacient and to expel placenta by the Cherokee and for cleaning the throat by the Iroquois (Austin, 2004). Much vaunted as a treatment for rabies with unlikely statistics (1,400 cases cured by one doctor alone). Also as ‘antispasmodic, nervine, [for] chorea, convulsions, tetanus, tremors, delirium tremens, [and as a] diaphoretic and diuretic'. Toxicity symptoms include mental confusion, stupor, headache, vertigo, photophobia, dilated pupils, difficulty in micturition, bradycardia, tremulousness and languor, followed by wakefulness and restlessness (Milspaugh, 1974). Hutchens (1991) reported that it reduces sexual desire and was used for almost every nervous illness. Scutellaria baicalensis contains baicalin, baicalein and wogonin (European Medicines Agency, September 2010). It is used in Traditional Chinese Medicine for treating inflammation, cancer, bacterial and viral infections of the lungs and gut and is one of the '50 Chinese herbs' in the lists of some authors. Scutellaria lateriflora (combined with Verbena officinalis, Passiflora incarnata and the seed of Avena sativa (oats) is licensed for use in Britain as a herbal medicine for temporary relief of mild symptoms of stress such as mild anxiety and to aid sleep, based upon traditional use only. Scutellaria baicalensis is not licensed for use in the UK (UK Medicines and Healthcare Products Regulatory Agency (MHRA)). Photographed in the Medicinal Garden of the Royal College of Physicians, London.
  • On the preparations of the Indian hemp, or gunjah, (Cannabis Indica) their effects on the animal system in health, and their utility in the treatment of tetanus and other convulsive disorders / [W.B. O'Shaughnessy].
  • Veratrum nigrum L. Melanthiaceae Distribution: Europe. Cows do not eat Veratrum species in the meadows, and human poisoning with it caused vomiting and fainting. In the 1850s it was found to reduce the heart's action and slow the pulse (Bentley, 1861, called it an 'arterial sedative'), and in 1859 it was used orally in a woman who was having convulsions due to eclampsia. Dr Paul DeLacy Baker in Alabama treated her with drops of a tincture of V. viride. She recovered. It was used thereafter, as the first choice of treatment, and, when blood pressure monitoring became possible, it was discovered that it worked by reducing the high blood pressure that occurs in eclampsia. By 1947 death rates were reduced from 30% to 5% by its use at the Boston Lying-in Hospital. It works by dilating the arteries in muscles and in the gastrointestinal circulation. A further use of Veratrum species came to light when it was noted that V. californicum - and other species - if eaten by sheep resulted in foetal malformations, in particular only having one eye. The chemical in the plant that was responsible, cyclopamine, was found to act on certain genetic pathways responsible for stem cell division in the regulation of the development of bilateral symmetry in the embryo/foetus. Synthetic analogues have been developed which act on what have come to be called the 'hedgehog signalling pathways' in stem cell division, and these 'Hedgehog inhibitors' are being introduced into medicine for the treatment of various cancers like chondrosarcoma, myelofibrosis, and advanced basal cell carcinoma. The drugs are saridegib, erismodegib and vismodegib. All the early herbals report on its ability to cause vomiting. As a herbal medicine it is Prescription Only, via a registered dentist or physician (UK Medicines and Healthcare Products Regulatory Agency (MHRA)). Photographed in the Medicinal Garden of the Royal College of Physicians, London.
  • Veratrum album L. Melanthiaceae Distribution: Europe. Cows do not eat Veratrum species in the meadows, and human poisoning with it caused vomiting and fainting. In the 1850s it was found to reduce the heart's action and slow the pulse (Bentley, 1861, called it an 'arterial sedative'), and in 1859 it was used orally in a woman who was having convulsions due to eclampsia. Dr Paul DeLacy Baker in Alabama treated her with drops of a tincture of V. viride. She recovered. It was used thereafter, as the first choice of treatment, and when blood pressure monitoring became possible, it was discovered that it worked by reducing the high blood pressure that occurs in eclampsia. By 1947 death rates were reduced from 30% to 5% by its use at the Boston Lying in Hospital. It works by dilating the arteries in muscles and in the gastrointestinal circulation. A further use of Veratrum species came to light when it was noted that V. californicum -and other species - if eaten by sheep resulted in foetal malformations, in particular only having one eye. The chemical in the plant that was responsible, cyclopamine, was found to act on certain genetic pathways responsible for stem cell division in the regulation of the development of bilateral symmetry in the embryo/foetus. Synthetic analogues have been developed which act on what have come to be called the 'hedgehog signalling pathways' in stem cell division, and these 'Hedgehog inhibitors' are being introduced into medicine for the treatment of various cancers like chondrosarcoma, myelofibrosis, and advanced basal cell carcinoma. The drugs are saridegib, erismodegib and vismodegib. All the early herbals report on its ability to cause vomiting. As a herbal medicine it is Prescription Only, via a registered dentist or physician (UK Medicines and Healthcare Products Regulatory Agency (MHRA)). Photographed in the Medicinal Garden of the Royal College of Physicians, London.
  • Valeriana officinalis L. Valerianaceae Valerianus, Phu, Nardus sylvestris, Setwal. Distribution: Europe. Popular herbalism attributes sedation to Valerian, but this is not mentioned by Coles (1657) or Gerard (1633) or Lobel (1576) or Lyte (1578) or Dioscorides (ex Gunther, 1959) or Fuchs (1553), where he quotes Pliny, Dioscorides and Galen, or Parkinson (1640), or Pomet (1712). The English translation of Tournefort (1719-1730) covers a whole page of the uses of all the different valerians, but never mentions sedation or treating anxiety. Quincy (1718) does not mention it. Because it was used in epilepsy, for which Woodville (1792) says it was useless, Haller, in his Historia stirpium indegenarum Helvetae inchoatae (1768) advocates it for those with irritability of the nervous system, as does Thomson's London Dispensatory (1811) although he lists it as an 'antispasmodic and stimulant' and for inducing menstruation. Lindley (1838) notes (as many did) that the roots smell terrible and that this makes cats excited, and in man, in large doses, induce 'scintillations, agitation and even convulsions' so used in asthenic fever, epilepsy, chorea, hysteria and as an antihelminthic.' Fluckiger & Hanbury (1879) give a wonderful account of the history of its names, but give its use as 'stimulant and antispasmodic' as do Barton & Castle (1877). but by 1936 (Martindale's Extra Pharmacopoeia) its only use was 'Given in hysterical and neurotic conditions as a sedative. Its action has been attributed to its unpleasant smell'. The European Medicines Agency (2006) approves its use as a traditional herbal medicine for mild anxiety and sleeplessness for up to 4 weeks. Despite what is written continuously about its use in ancient Greece and Rome, the only reason for its use has been because it was thought, for a brief while, to be good for epilepsy and therefore might deal with persons of a nervous disposition because of its foul smell. It has been suggested that even its Greek name, 'Phu' came from the expression of disgust which is made when one sniffs an unpleasant odour. For 1,800 years, before the last century, no-one had thought it sedative. Photographed in the Medicinal Garden of the Royal College of Physicians, London.
  • Asphodeline lutea Rchb. Yellow asphodel, King's spear, Hastula regia. Hardy rhizomatous perennial. Distribution Mediterranean and Caucasus. It is the flower of the dead, as Homer writes that it carpets an area in the gloomy darkness of the underworld (Hades), in Greek mythology where the souls of the dead are found. However this may be a misinterpretation of the Greek where 'Asphodel' has been read instead of 'ash-filled'. In the etymology of flower names, it is suggested that the yellow 'daffodil' is a corruption of French or Flemish 'de asphodel' (both ex Steve Reece, 2007). An Aristotelian epigram, refers to it growing on tombs: 'On my back I hold mallow and many-rooted asphodel ...' The asphodel was sacred to Persephone, goddess of the underworld, who was seized and wed by Hades, god of the underworld, and taken to his kingdom. Her disappearance brings the winter, and her reappearance each year, the spring. The only reliable source of information about its early medical uses is, probably, Dioscorides although the plant in his De Materia Medica may be A. ramosus or A. albus. He gives its properties as diuretic, induces menses, good for coughs and convulsions, an antidote to snake bite, applied as a poultice for sores of all sorts, and in compounds for eye, ear and tooth pains, and to cure alopecia and vitiligo, but induces diarrhoea and vomiting and is an anti-aphrodisiac. Fuchs (1542), as Ruel’s commentaries (1543) note, makes a big mistake as he has Lilium martagon as his concept of A. luteus. Ruel only illustrates its leaves and roots, calling it Hastula regia (Latin for King’s spear) but Matthiolus's Commentaries (1569 edition) has a reasonable woodcut also as Hastula regia (1569). Dodoen's Cruydeboeck (1556) does not mention or illustrate Asphodelus luteus. L'Escluse's French translation Histoire des Plantes (1557) follows the Cruydeboeck. Dodoen's Latin translation Stirpium Historia Pemptades Sex (1583) adds A. luteus with text and woodcut, with no uses. Henry Lyte's (1578) translation illustrates Asphodelus luteus as Asphodeli tertia species and 'Yellow affodyl' (vide etymology of 'daffodil') and also does not describe any uses for it. Gerard's translation The Herbal (1597 and 1633) continues the muddle and does not give any uses for this plant. Parkinson's comments (1640) on the lack of medicinal properties of asphodels, refer to quite different plants coming from wet areas in Lancashire, Scotland and Norway . He calls them pseudoasphodelus major and minor which he writes are called Asphodelus luteus palustris by Dodoens, and not 'King's Spear' which he illustrates with a good woodcut of A. luteus and calls it Asphodelus luteus minor. Once herbals started to be written in northern Europe, the knowledge of the arid loving, Asphodelus luteus of south east Europe was lost. Photographed in the Medicinal Garden of the Royal College of Physicians, London.
  • Dr. Willis's Practice of physick, being the whole works of that renowned and famous physician: containing these eleven several treatises, viz. I. Of fermentation. II. Of feavers. III. Of urines. IV. Of the accension of the blood. V. Of musculary motion. VI. Of the anatomy of the brain. VII. Of the description and use of the nerves. VIII. Of convulsive diseases. IX. Pharmaceutice rationalis, the first and second part. X. Of the scurvy. XI. Two discourses concerning the soul of brutes. Wherein most of the diseases belonging to the body of man are treated of, with excellent methods and receipts for the cure of the same. Fitted to the meanest capacity by an index for the explaining of all the hard and unusual words and terms of art derived from the Greek, Latine, or other languages for the benefit of the English reader. With forty copper plates / The Pharmaceutice new translated [as also the remainder, by Samuel Pordage], and the whole carefully corrected. And amended.
  • Dr. Willis's Practice of physick, being the whole works of that renowned and famous physician: containing these eleven several treatises, viz. I. Of fermentation. II. Of feavers. III. Of urines. IV. Of the accension of the blood. V. Of musculary motion. VI. Of the anatomy of the brain. VII. Of the description and use of the nerves. VIII. Of convulsive diseases. IX. Pharmaceutice rationalis, the first and second part. X. Of the scurvy. XI. Two discourses concerning the soul of brutes. Wherein most of the diseases belonging to the body of man are treated of, with excellent methods and receipts for the cure of the same. Fitted to the meanest capacity by an index for the explaining of all the hard and unusual words and terms of art derived from the Greek, Latine, or other languages for the benefit of the English reader. With forty copper plates / The Pharmaceutice new translated [as also the remainder, by Samuel Pordage], and the whole carefully corrected. And amended.
  • An epileptic or sick person having a fit on a stretcher, two men try to restrain him. Ink drawing attributed to J.B. Jouvenet.
  • An epileptic or sick person having a fit on a stretcher, two men try to restrain him. Ink drawing attributed to J.B. Jouvenet.
  • An epileptic or sick person having a fit on a stretcher, two men try to restrain him. Ink drawing attributed to J.B. Jouvenet.
  • Thomas Willis, Pathologiae cerebri, 1679
  • Balthasar Bekker and Christian Scriver sieve diseases from devils. Engraving, 1731.