concept

Balanced translocation 45,XY,t(13;14)

Unbalanced translocation 46,XY,t(14;21)

Pericentric chromosome inversion

Unbalanced translocation 46,XY,t(13;14)

Inheritance of translocations

Leukamia karyotype t(8;14)

Balanced translocation 46,XY,t(4;10)

XYY syndrome karyotype 46,XYY

Chronic myeloid leukaemia karyotype 9;22

Fragile X metaphase spread

Inversion in the X chromosome 46,X,inv(X)9p21.2?q22.3. One of this pair of human X chromosomes contains a segment that has been broken off then rejoined the opposite way round.

Inversion in X chromosome

Human karyotype - acute myelomonocytic leukaemia with eosinophilia (FAb subtype M4E0) inv 16. There is an inversion on chromosome 16.
Image by Dr Fiona Ross.

Acute myelomonocytic leukaemia +eosinophilia

Paracentric inversion 46,XY,inv(5)(q13q15). This male has a chromosomal disorder. Part of one of the arms of chromosome 5 has broken off and rejoined the opposite way round.

Paracentric chromosome inversion

Trisomy 18 syndrome (formerly Edward's syndrome) karyotype, 47,XY,+18 This human male has a normal chromosome complement, plus an extra chromosome 18. Symptoms include growth failure, mental retardation, hypertonicity, rocker-bottom flatfoot, flexion defomities of the fingers, and renal and cardiac anomalies. Sufferers seldom survive beyond six months. The syndrome is associated with advanced maternal age.

Edward's syndrome karyotype, 47,XY,+18

genetic information, so the translocation is said to be balanced.

Balanced reciprocal translocation 46,XY,t(2;5). This male has a chromosomal disorder. A chromosome 2 and a chromosome 5 have exchanged segments. The cell still contains a complete complement of

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Karyotype

Images

Catalogue

Inversion in X chromosome

Acute myelomonocytic leukaemia +eosinophilia

Paracentric chromosome inversion

Edward's syndrome karyotype, 47,XY,+18

Balanced reciprocal translocation 46,XY,t(2;5). This male has a chromosomal disorder. A chromosome 2 and a chromosome 5 have exchanged segments. The cell still contains a complete complement of

Wellcome uses cookies.

Karyotype

Images

Catalogue

Inversion in X chromosome

Acute myelomonocytic leukaemia +eosinophilia

Paracentric chromosome inversion

Edward's syndrome karyotype, 47,XY,+18

Balanced reciprocal translocation 46,XY,t(2;5). This male has a chromosomal disorder. A chromosome 2 and a chromosome 5 have exchanged segments. The cell still contains a complete complement of

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