concept

Human metaphase, translocation, cosmid probe

Turner's syndrome, centromere & cosmid probe

Duchenne muscular dystrophy control, FISH

Aniridia + translocation, FISH & cosmid prob

Translocation shown up by cosmid probes

Translocation - use of cosmid probe

Familial aniridia deletion shown by cosmid

Duchenne muscular dystrophy deletion, FISH

Translocation, shown by cosmid probes

Translocation shown up by cosmid probe

Human chromosomes highlighted by fluorescent
probes that bind to specific sequences of DNA.
This patient has Turner's syndrome and a
45,X/46,Xr(X) mosaic karyotype. The X chromosome
centromere probe (green) shows that the small ring
chromosome is of X origin and the XIST cosmid
(red) shows that XIST is deleted in this r(X).
(See also B0000316C)
Image by Dr John Crolla.

Turner's stndrome, centromere & cosmid probe

Human chromosomes from a patient with Hereditary
Liability to Pressure Palsy (a lesion of a spinal
root or peripheral nerve resulting from
compression). There is a deletion in chromosome 17
(17p11.2), which has been highlighted using a
fluorescent cosmid probe (red) from the PMP gene.
The chromosome 11 centromeres are green. The
chromosomes have been highlighted with fluorescent
probes that bind to specific sequences of DNA.
Image by Dr John Crolla.

Pressure palsy, deletion c'some 17, cosmid

Chromosomes from a patient with isolated familial
aniridia. The chromosomes have been made
fluorescent with probes that bind to specific
sequences of DNA. A cosmid probe F02121 (red) shows
up the deletion in chromosome 11, and a green
fluorescent probe shows up the chromosome 11
centromeres.
This condition involves the developmental absence
of most of the iris. Its base is present on the
ciliary body, and often upsets the aqueous
outflow mechanism. Also called irideremia.
Image by Dr John Crolla.

Human chromosomes highlighted by fluorescent
probes which bind to specific sequences of DNA.
The FISH (fluorescence in situ hybridisation)
study is of a female heterozygous for a deletion
in the Duchenne muscular dystrophy (DMD) gene. The
DMD cosmid probe is red, the X chromosome
centromeres are green.
See B0000325C for control.
Image by Dr John Crolla.

Human chromosomes at metaphase, highlighted by
fluorescent probes that bind to specific base
sequences on the DNA. This cell has a
translocation between the X chromosome and a
chromosome 13 (X;13). The cosmid probe from the
XIST region (red) has not been disrupted by the Xq
break point. The use of such probes can help to
determine the break-points in the translocation.
(See also B0000313C)
Image by Dr John Crolla.

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COSMID

Images

Catalogue

Turner's stndrome, centromere & cosmid probe

Pressure palsy, deletion c'some 17, cosmid

Familial aniridia deletion shown by cosmid

Duchenne muscular dystrophy deletion, FISH

Translocation - use of cosmid probe

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COSMID

Images

Catalogue

Turner's stndrome, centromere & cosmid probe

Pressure palsy, deletion c'some 17, cosmid

Familial aniridia deletion shown by cosmid

Duchenne muscular dystrophy deletion, FISH

Translocation - use of cosmid probe

Wellcome Collection

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