Chemorepulsion of DRG sensory neuron

Sensory neuron from an adult dorsal root ganglion immunostained for Growth Associated Protein (GAP43) shown in red. Neurites are growing in between stripes containing the EphrinA5 protein (green). When the cell processes come into contact with this protein they are repelled and therefore grow along between the stripes. The effects of the Ephrin molecules are mediated through a family of tyrosine kinase receptors. The EphrinA5 protein is important in providing repulsive signals during the development of the nervous system. Biomedical Image Awards 1999.